Systemic sclerosis disease

Systemic scleroderma, or systemic sclerosis, is an autoimmune rheumatic disease characterised by excessive production and accumulation of collagen, called fibrosis, in the skin and internal organs and by injuries to small arteries. There are two major subgroups of systemic sclerosis based on the extent of skin involvement: limited and diffuse Systemic sclerosis is a complex autoimmune disease characterized by a chronic and frequently progressive course and by extensive patient-to-patient variability. Like other autoimmune diseases, systemic sclerosis occurs more frequently in women, with a peak of onset in the fifth decade of life

Systemic scleroderma - Wikipedi

Systemic sclerosis - PubMe

  1. The Safety and Efficacy of Nintedanib in Systemic Sclerosis (SENSCIS) trial suggested as much after nintedanib effectively slowed the decline in lung function in patients with systemic sclerosis-associated ILD (SSc-ILD). 3 Despite a relatively small treatment effect compared with that reported in studies of idiopathic pulmonary fibrosis,
  2. One of the earliest signs of systemic scleroderma is Raynaud's disease, which causes the small blood vessels in your fingers and toes to contract in response to cold temperatures or emotional distress. When this happens, your fingers or toes may turn blue or feel painful or numb. Raynaud's disease also occurs in people who don't have scleroderma
  3. Scleroderma is a symptom of several rheumatic diseases (conditions characterized by inflammation and pain in the muscles, joints, or fibrous tissue) and connective tissue diseases. Many rheumatologists refer to the overall disease process as systemic sclerosis and the skin involvement as scleroderma
  4. Multiple Sclerosis is a chronic autoimmune, T-cell mediated inflammatory disease affecting the central nervous system whereas systemic sclerosis, also known as scleroderma, is an autoimmune multisystem disease with a progressively worsening clinical picture
  5. Request PDF | On Jan 6, 2021, Nina M van Leeuwen and others published Disease progression in Systemic Sclerosis | Find, read and cite all the research you need on ResearchGat
  6. Juvenile systemic sclerosis (JSSc) is a rare disease of childhood and currently no international consensus exists with regard to its assessment and treatment
  7. Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by aberrant immune activation, vascular injury followed by defective neovascularization and impaired remodeling, and extensive tissue fibrosis of the skin and certain internal organs

Systemic sclerosis is a complex multisystem autoimmune disease characterized by inflammation, vascular pathology, and widespread fibrosis that affects multiple organ systems. Two hallmarks of the disease include skin fibrosis and interstitial lung disease which includes idiopathic pulmonary fibrosis. Currently, there is no cure for this disease and drug development has bee Systemic sclerosis is a condition that is marked by the abnormal growth of connective tissue, like collagen, in your body. This tissue supports your skin and internal organs. Andrew Brookes / Getty Images It is considered an autoimmune disease; your body's immune system starts treating your skin and other tissues as a foreign invader Systemic sclerosis-interstitial lung disease with coexistent subacute invasive pulmonary aspergillosis: a rare association. Authors: Benhur Joel Shadrach Kunal Deokar Vikrant Agarwal Anukool Jain Rishabh Goel. Adv Respir Med 2021 Jan 20. Epub 2021 Jan 20 Systemic sclerosis is a rare and heterogeneous autoimmune disease characterized by immune dysregulation, microvascular damage, and organ fibrosis. 1 Interstitial lung disease (ILD) is a common. Systemic sclerosis is a rare condition that can cause people's skin and the connective tissue inside the body to harden. You can sometimes see signs of systemic sclerosis on the face, hands, feet and elsewhere around the body, as skin hardens and thickens

Scleroderma is an uncommon condition that results in hard, thickened areas of skin and sometimes problems with internal organs and blood vessels. Scleroderma is caused by the immune system attacking the connective tissue under the skin and around internal organs and blood vessels. This causes scarring and thickening of the tissue in these areas Treatment of systemic sclerosis-associated interstitial lung disease : a work in progress. / Oldham, Justin M. In: The Lancet Respiratory Medicine, Vol. 9, No. 1, 01.2021, p. 5-7. Research output: Contribution to journal › Comment/debate › peer-revie Arthritis Rheumatol. 2021 Jan 17. doi: 10.1002/art.41657. Online ahead of print. ABSTRACT. OBJECTIVE: To identify the genetic variants that affect gene expression (expression quantitative trait loci, eQTLs) in systemic sclerosis (SSc) to investigate their role in the pathogenesis of the disease One-third of patients with systemic sclerosis have lcSSc: sclerosis is limited to the digits, distal limbs (not spreading more proximal than the elbows or knees) and face. LcSSc progresses more slowly than dcSSc and with less internal organ involvement except there is a risk of pulmonary artery hypertension , especially later in the disease course The cause of systemic sclerosis is not known. The disorder is 4 times more common among women and most common among people aged 20 to 50. It is rare among children. Symptoms of systemic sclerosis may occur as part of mixed connective tissue disease, and some people with mixed connective tissue disease ultimately develop severe systemic sclerosis

Systemic sclerosis is a rare, chronic autoimmune rheumatic disorder characterized by degenerative changes and scarring in the skin, joints, and internal organs and by blood vessel abnormalities. The cause of systemic sclerosis is unknown Systemic sclerosis (SSc) is an orphan disease characterised by autoimmunity, fibrosis of the skin and internal organs, and vasculopathy. SSc may be associated with high morbidity and mortality Systemic sclerosis is a rare disease characterised by vascular abnormalities and fibrosis of multiple organs. Proactive screening and follow up for organ-specific complications are important aspects of management Scleroderma, which means hard skin, is a rare disease that affects the skin and connective tissue (fibers that provide structure and support to the body). There are two types of scleroderma - localized and systemic (sometimes called systemic sclerosis). Localized scleroderma mainly affects the skin and is more common in children; systemic. Systemic sclerosis (SSc) is a rare but potentially life-threatening rheumatological condition with a wide range of signs and symptoms. This article describes the GP's key role in the early diagnosis of SSc and discusses the current and emerging treatment options

Disease activity indices in systemic sclerosis: a systematic literature review. Melsens K(1), De Keyser F(2), Decuman S(3), Piette Y(4), Vandecasteele E(5), Smith V(2). Author information: (1)Department of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University, Belgium. karin.melsens@ugent.be Systemic sclerosis is a complex autoimmune disease characterized by a chronic and frequently progressive course and by extensive patient-to-patient variability. Like other autoimmune diseases,.. Systemic sclerosis (SSc) is a complex autoimmune rheumatic disease that is characterised by widespread skin and internal organ fibrosis, immune system dysregulation, and vasculopathy. The disease.. Background/Purpose: Previous studies have demonstrated alterations in GI microbiota of patients with systemic sclerosis (SSc) compared with healthy controls [1]. However, these prior studies did not adequately examine the impact of disease features and patient characteristics on microbial composition. The purpose of the present study was to examine associations between specific SSc disease. Systemic scleroderma (SSc), also known as systemic sclerosis, is a chronic connective tissue disease that is characterized by vasculopathy, autoimmunity, and inflammation. 1,2 As SSc develops, the body's fibroblasts produce too much collagen, leading to fibrosis of the skin and the internal organs. 1,3 It was not until the 20th century that scleroderma was shown to affect the internal organs—resulting in the devastating outcomes that are now associated with SSc

Systemic Sclerosis - Multidisciplinary Disease: Clinical

Systemic sclerosis is one of the most complex, systemic autoimmune diseases in which inflammation and fibrosis play a crucial role, leading to severe damage and failure of multiple organs. 1,2 Its cause is unknown, and it is characterized by immune system activation, vasculopathy, and widespread tissue fibrosis of the skin and certain internal organs In 1945 Goetz, emphasizing the widespread and generally worsening visceral involvement seen in some individuals with scleroderma, proposed the term progressive systemic sclerosis. Today we recognize that progressive systemic sclerosis, a whole body disease, can have both diffuse cutaneous involvement and limited cutaneous involvement Scleroderma is a group of diseases that cause abnormal growth of connective tissue (such as morphea, systemic sclerosis, CREST syndrome). Learn more

Systemic sclerosis (SSc) is a systemic autoimmune disease that is characterised by endothelial dysfunction, resulting in small-vessel vasculopathy, immune dysregulation, fibroblast dysfunction and subsequent fibrosis; however, its detailed pathogenesis remains unclear [ 1 ] Progressive systemic sclerosis is an autoimmune disease that causes problems with the skin, joints, and internal organs. The defining characteristic of the disease is an overproduction of collagen, a type of connective tissue, in the body.When there is too much collagen, areas of the skin thicken and harden, joints become less mobile, and vital blood vessels are damaged Systemic Sclerosis (Scleroderma) Systemic Sclerosis (SSc) or Scleroderma is a rare disease characterized by hardening of the skin due to a build-up of fibrous scar tissue, causing a tight and shiny appearance. The most common area affected by the disease is the fingers, however many other areas can be affected Systemic sclerosis is a form of scleroderma that can not only affect the skin and underlying tissue, but also the internal organs. In this study, 23andMe researchers aim to learn more about the genetics of people living with the disease in order to search for clues that could ultimately lead to the development of better treatments

Progressive Skin Fibrosis - Photo Quiz - American Family

Systemic sclerosis, an autoimmune disease characterized by fibrosis of the skin and various internal organs, is associated with cardiovascular abnormalities including pulmonary hypertension, atherosclerosis, right and left ventricular dysfunction, arrhythmias, conduction defects, pericardial disease, and valvular heart disease Systemic sclerosis is a rare chronic disease of unknown cause characterized by diffuse fibrosis and vascular abnormalities in the skin, joints, and internal organs (especially the esophagus, lower gastrointestinal tract, lungs, heart, and kidneys) Introduction • Chronic systemic connective tissue disorder. • Characterised by thickening of the skin (scleroderma) and distinctive involvement of multiple internal organs most notably lungs,GIT, heart, kidneys. 4. Background • Scleroderma is derived from the greek words skleros (hard or indurated) and derma (skin)

Disease-related and psychosocial factors associated with depressive symptoms in patients with systemic sclerosis, including fear of progression and appearance self-esteem. J Psychosom Res . 2012. Pericardial disease is clinically apparent in 5% to 16% of patients with systemic sclerosis 81; patients with limited cutaneous systemic sclerosis have more pericardial disease than those with diffuse cutaneous systemic sclerosis (30% vs. 16%). 82 Forty-one percent of systemic sclerosis patients have been shown to have pericardial effusion by echocardiography, 81 but the effusions are. Systemic sclerosis (SSc) is a rare autoimmune disease, frequently complicated by interstitial lung disease (ILD), which is associated with worse outcomes. 1-5 Some patients with SSc-associated ILD (SSc-ILD) develop progressive ILD, showing decline in lung function and/or increasing extent of fibrosis by high-resolution CT (HRCT). 4-10 The proportion of patients with SSc-ILD who develop progressive ILD and the pattern of disease course in these patients are incompletely understood

Systemic sclerosis (SSc) is a multisystem autoimmune disease in which there is increased fibroblast activity resulting in abnormal growth of connective tissue. This causes vascular damage and fibrosis. Fibrosis occurs in skin, the gastrointestinal (GI) tract, heart, lungs and other internal organs Introduction. Systemic sclerosis is an immune-mediated disease that represents a major clinical challenge for physicians and patients. Systemic sclerosis has a high mortality—greater than any other rheumatic disease—despite evidence of improved survival, especially for patients with diffuse cutaneous systemic sclerosis.1, 2 For the patient, systemic sclerosis is associated with great. Purpose of review . This review provides a risk-stratified and evidence-based management for subsets of systemic sclerosis (SSc) patients in the first five years from disease onset.. Recent findings . Cardiopulmonary disease remains the primary cause of mortality in SSc patients

Systemic sclerosis is a rare multisystem disorder characterised by vascular abnormalities, connective tissue sclerosis and atrophy, and the presence of autoantibodies. There is both cutaneous and systemic involvement, with gastrointestinal, respiratory, cardiac, and renal complications Interstitial lung disease associated with systemic sclerosis (SSc-ILD) is one of the important pulmonary manifestations of systemic sclerosis. It usually gives a NSIP type pattern with an UIP pattern occurring less commonly 7. It can sometimes produce a rapidly progressive interstitial lung disease pattern 1

Systemic Sclerosis - The Lance

  1. Undifferentiated Connective Tissue Disease at risk for Systemic Sclerosis (UCTD-risk-SSc), otherwise referred to as very early-early SSc (very early-early diagnosis of systemic sclerosis VEDOSS), is a condition characterized by Raynaud's phenomenon (RP) and either SSc serum marker autoantibodies or a capillaroscopic scleroderma pattern or both, but without satisfying classification criteria.
  2. Systemic scleroderma includes a wide range of symptoms including inflammatory diseases of the muscles (i.e., polymyositis or dermatomyositis), swelling (edema) of the fingers and/or hands, microvascular abnormalities, lung disease (i.e., progressive interstitial fibrotic pulmonary disease), kidney dysfunction (i.e., rapidly progressive renal failure), cardiovascular problems (i.e., myocardial.
  3. Close monitoring of patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD) and awareness of the variable course of progression is highly important in considering when to initiate treatment, according to study results published in the Annals of the Rheumatic Diseases.. Some patients with SSc-ILD may develop progressive ILD, which is associated with higher mortality, and.
  4. systemic sclerosis: [ sklĕ-ro´sis ] an induration or hardening , especially of a part from inflammation, or in disease of the interstitial substance. The term is used chiefly for such a hardening of the nervous system due to hyperplasia of the connective tissue or for hardening of the blood vessels. Called also induration . adj., adj.
  5. Systemic sclerosis (SSc) is a chronic, autoimmune disease which can affect the blood vessels, the visceral organs, and the skin. SSc, most commonly, develops between the ages of 30 and 50, but it can be seen at any age. In terms of skin involvement, SSc can be classified as limited or diffuse. Its etiopathogenesis is still unclear
  6. ed by how extensive the skin involvement is
  7. Systemic sclerosis: A progressive multisystem autoimmune disease1,2. A complex of features with high patient-to-patient variability3-6. Fibrosisis a characteristic process in all forms of systemic sclerosis (SSc) Raynaud's phenomenonis the most common first sign. Skin thickening

1. Introduction. Systemic Sclerosis (SSc), characterized by skin, joint, and muscle modifications, leads to disability and impairs health related quality of life (QoL) [].As a consequence of chronicity, SSc patients report high level of pain, fatigue, and impaired physical functioning [2, 3].SSc often disfigures the most visible and socially relevant parts of the body like the face and the hands Patients with systemic sclerosis that overlaps with systemic lupus erythematous are generally younger at the time of diagnosis, more frequently demonstrate pulmonary arterial hypertension and less. Systemic sclerosis sine scleroderma: patients with this form of the disease do not all have skin manifestations. Vascular Disease: Raynaud's phenomenon is the most common symptom that is caused by blood vessel disease Systemic sclerosis (SSc) is a heterogeneous autoimmune disorder associated with vascular dysfunction and fibrotic changes in the skin, vasculature and internal organs. Although serologic abnormalities are an important diagnostic tool for SSc, little is known about whether autoantibodies precede clinical diagnosis. Here we investigated the presence of autoantibodies before SSc diagnosis and.

Systemic Sclerosis - European Medical Journa

Systemic sclerosis (SSc) is the most commonly associated CTD with PAH, and this has led to a major focus on screening cases to make the diagnosis as early as possible.2,3 This offers an opportunity to improve outcome since earlier treatment may be associated with better long-term outcome.4 SSc provides a paradigm for investigation and treatment. Systemic sclerosis (Ssc) is a rare disease in which collagen gloms up internal organs and toughens the skin into an armor of sorts. It's also called scleroderma, from the Greek for hard (skleros) and skin (derma).Ssc is autoimmune, not inherited, but a recent report in JCI Insight describes how gene expression profiling — transcriptomics - can add precision to diagnosis.

Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is a devastating complication of SSc, with high morbidity and mortality, and limited effective treatments. In SSc-ILD, myofibroblasts are the key fibrotic effector cell due to their excessive extracellular matrix production and acquired contractile phenotype INTRODUCTION. Cardiac involvement is common in systemic sclerosis (SSc) and is often unrecognized until late in the disease course. All aspects of the heart can be affected, including the myocardium, pericardium, and conduction system, although typically one manifestation predominates in a particular patient Patients with primary biliary cirrhosis (PBC) often have concurrent limited systemic sclerosis (SSc). Conversely, up to one-fourth of SSc patients are positive for PBC-specific antimitochondrial antibodies (AMA). The mechanisms responsible for the co-occurrence of these diseases are largely unknown. Genetic, epigenetic, environmental, and infectious factors appear to be important for the.

Systemic sclerosis is associated with immune dysregulation, microvascular damage, and organ fibrosis. A common manifestation of systemic sclerosis is interstitial lung disease which is a leading cause of death in patients with systemic sclerosis Systemic sclerosis 1. Systemic Sclerosis (definition) • Multisystem disorder • Unknown etiology • Thickening of skin caused by accumulation of connective tissue (collagen types I and III) • Involvement of visceral organs 2. Epidemiology • Peak age range: 35-64 • Younger age in women and with diffuse disease Systemic sclerosis (SSc) is a rare connective tissue disease with a heterogeneous clinical course. Interstitial lung disease (ILD) is a common manifestation of SSc and a leading cause of death. All patients newly diagnosed with SSc should receive a comprehensive clinical evaluation, including assessment of respiratory symptoms, a high-resolution computed tomography (HRCT) scan of the chest. Disease definition Systemic sclerosis (SSc) is a generalized disorder of small arteries, microvessels and connective tissue, characterized by fibrosis and vascular obliteration in the skin and organs, particularly the lungs, heart, and digestive tract

Systemic diseases are diseases that involve many organs or the whole body. Many of these diseases also affect the eyes. In fact, an eye exam sometimes leads to the first diagnosis of a systemic disease. Multiple sclerosis - a disease that damages nerve coverings,. Systemic sclerosis (SSc) is an autoimmune systemic disease characterized by small vessel involvement that leads to tissue ischemia and fibroblast stimulation resulting in accumulation of collagen (fibrosis) in the skin and internal organs. The peak incidence of the disease is found between the third and fifth decade of life Systemic sclerosis is an uncommon disease of the immune system that leads to scarring and damage to the skin, blood vessels and internal organs including the heart, lungs, kidneys and bowel. Ii is not curable but can be treated with powerful drugs, including those which suppress the immune system and some that are also used as cancer chemotherapy pulmonary manifestations of systemic sclerosis, which is a multifactorial autoimmune disease characterized by deposition of autoantibodies and collagen that result in fibrosis of skin and dysfunction of multiple organs (most commonly skin, lungs, gastrointestinal tract) Systemic sclerosis is a severe subtype of scleroderma that results in fibrosis of the skin and internal organs, such as the stomach, intestines, lungs, heart, and kidneys. Rare Disease A disease is deemed rare if it affects fewer than 200,000 people in the United States

Systemic scleroderma: MedlinePlus Genetic

Systemic Sclerosis Also called scleroderma, systemic sclerosis is a diffuse connective tissue disease.. Systemic sclerosis In systemic sclerosis, internal organs can be affected as well as the skin.This type mostly affects women and usually develops between 30 and 50 years of age. Children are rarely affected Scleroderma or systemic sclerosis (SSc) is a systemic multi-organ disorder characterized by autoimmunity, systemic inflammation, vascular injury, and tissue fibrosis (1). Hippocrates provided the first description of their thickened skin texture around 400 BCE followed by labeling of the skin as wood-like by Curzio (2) Systemic sclerosis (SSc) is a connective tissue disease (CTD) characterized by organ fibrosis and vasculopathy with an autoimmune background [1]. The hallmark of immunological abnormality in SSc patients is autoantibodies detected from their serum; anti-nuclear antibody (Ab) is detected from more than 90% of the patients [2] Whole body autopsy reports were used to develop a global score of systemic vascular disease that included aorta and coronary artery atheroma, cardiac hypertensive disease, myocardial infarction and..

Systemic scleroderma Genetic and Rare Diseases

  1. Sometimes, however, the disease affects the lungs or heart, with potentially serious results. Limited scleroderma has no known cure. Treatments focus on managing symptoms, preventing serious complications and improving quality of life. Systemic sclerosis: Diffuse and limited
  2. Systemic sclerosis mimics include a variety of diseases that may resemble systemic connective tissue diseases such as SSc. Above all, the most common diseases are discussed in this chapter. The basis of proper diagnosis and treatment is the interdisciplinary collaboration of rheumatology and dermatology with the possibility of biopsy tissue collection and histological verification of the disease
  3. Systemic sclerosis (scleroderma) can affect every part of the body, including the skin, blood vessels, and all of the internal organs. There are also dozens of associated conditions and related autoimmune diseases
  4. Systemic Sclerosis Interstitial Lung Disease (SSc-ILD): The Importance of Early Diagnosis, Patient Centered Communication, and Evidence-Based Treatment Authors: Amy Olson, MD, MSPH; Virginia Steen, MD; Zulma Yunt, MD CME Released: 11/24/202
  5. Scleroderma (also called systemic sclerosis or SSC) is a rare disease characterized most often by skin thickening. Scleroderma also may involve internal organs. This often leads to intestinal, kidney, lung and heart problems. Scleroderma that affects other organs may be referred to as CREST syndrome
  6. Systemic sclerosis is a rare autoimmune disease characterised by a multifactorial aetiology involving a gene-environment interaction. Despite the growing epidemiological arguments for odds ratio (OR) data showing an association with occupational exposure, systemic sclerosis is not currently included in the list of recognised occupational diseases in Switzerland, unlike other northern European countries
  7. Systemic sclerosis aka Scleroderma is an autoimmune connective tissue disorder. Other similar diseases include SLE, RA, Sjogren's syndrome and mixed connective tissue disease. There is a lot of overlap in the symptoms of these diseases. Many will require immunosuppressive therapy
Scleroderma | Sickness FinderScleroderma Symptoms - Scleroderma Education Project

Background/Purpose: Feared complications of systemic sclerosis (SSc) affect the pulmonary system, with pulmonary hypertension and interstitial lung disease being common causes of mortality. Baseline and annual transthoracic echocardiography (TTE) screening for pulmonary hypertension in asymptomatic patients is recommended by experts from the. scleroderma (also known as systemic sclerosis, or SSc) is much more than a skin disorder Systemic sclerosis. Systemic sclerosis, or scleroderma, is an autoimmune multisystemic disease. There are two main clinical subtypes: a limited form mainly characterized by acral cutaneous sclerosis (lSSc) and a more diffuse variety (dSSc) Patients with diffuse systemic sclerosis will frequently be instructed to check their blood pressures regularly, and this is done to catch scleroderma kidney disease at its most early stage - when treatment is the most effective

Pain chronification and the important role of non-disease

Systemic sclerosis (SS) can involve the pericardium, myocardium, conduction system, and cardiac valves. The presence of overt clinical signs of cardiac disease is a poor prognostic sign. Clinical manifestations include dyspnea, palpitations, chest pain, syncope, and symptoms of right heart failure About Systemic Sclerosis-Associated Interstitial Lung Disease Systemic sclerosis is auto immune rheumatic disorder which is caused by an overproduction of collagen and proteins in parts of the body which results in scarring in joints, skin, blood vessels and other organs Systemic sclerosis (SSc) is a connective tissue disease clinically characterized by different degrees of skin fibrosis and visceral organ involvement (17,19,22) Systemic sclerosis (SSc) is a complex autoimmune disease with a range of manifestations, including vasculopathy, Raynaud's phenomenon, immune dysfunction, and fibrosis of the skin and internal organs (1-3).It is a rare disease, with an estimated global prevalence of 3 to 24 per 100,000 ().Diagnostic criteria for SSc were published jointly by the European League against Rheumatism and the.

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Treatment of systemic sclerosis-associated interstitial

Introduction: Systemic sclerosis is a chronic autoimmune disease, characterized by the triad of small vessel vasculopathy, immune system activation and increased deposits of extracellular matrix in the skin and internal organs Systemic sclerosis (SSc) is a complex rheumatologic autoimmune disease in which inflammation, fibrosis, and vasculopathy share several pathogenic pathways that lead to skin and internal organ damage. Recent findings regarding the participation and interaction of the innate and acquired immune system have led to a better understanding of the pathogenesis of the disease and to the identification. 2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative. Annals of the Rheumatic Diseases 2013, 72 (11): 1747-5

Blood‑patch pleurodesis for pneumothorax in lung fibrosisCongenital Rubella Syndrome : Systemic Conditions : The"Butterfly Rash" | Holistic medicine, Lupus awareness

Systemic sclerosis (SSc) is a debilitating, chronic autoimmune disease that causes the body's immune system to attack its own tissue. The underlying cause is unknown and it is potentially fatal. There are two main types, limited cutaneous and diffuse cutaneous Lung‐epithelial‐derived surfactant protein (SP-D) has been identified as a biomarker of systemic sclerosis-interstitial lung disease (SSc-ILD), according to a study published in Arthritis & Rheumatology. Other predictive markers include chemokine (C-C motif) ligand 18 (CCL18) for progression of ILD and Krebs von den Lungen-6 (KL-6) for acuteness of lung fibrosis Diffuse cutaneous Systemic Sclerosis (35% of cases) Skin involvement may be proximal to elbows and knees and may affect face; Associated with Interstitial Lung Disease (pulmonary fibrosis) May present with renal disease; Skin pigment may be altered; Tendons friction rubs may be present; Systemic Sclerosis sine Scleroderma (5% of cases

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